Begin by selecting one of four characters: Ironclad, Silent, Defect, or Watcher, each with unique cards and playstyles. Your goal is to ascend the Spire by defeating enemies and bosses across multiple acts. After each battle, choose from card rewards to build your deck, focusing on synergies (e.g., combining poison cards for Silent or strength-scaling attacks for Ironclad). Explore the map, balancing risky paths (elite fights for better rewards) with safer ones (rest sites for healing). Manage resources like health, gold, and energy carefully, and leverage relics to enhance your strategy. Experiment with different builds to adapt to the Spire’s randomness.